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Which chaperones are found in the cytosol, and what family do they belong to, and what do they respond to?

a) Hsp60, Heat Shock Proteins, respond to unfolded proteins
b) Hsp90, Heat Shock Proteins, respond to misfolded proteins
c) Hsp70, Heat Shock Proteins, respond to unfolded proteins
d) Hsp40, Heat Shock Proteins, respond to misfolded proteins

1 Answer

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Final answer:

Hsp70, which belongs to the Heat Shock Protein family in the cytosol, responds to unfolded proteins by assisting in their proper folding, especially during cellular stress like increased temperature.

Step-by-step explanation:

Among the chaperones found in the cytosol, Hsp70 is one that belongs to the Heat Shock Proteins family and responds to unfolded proteins. Chaperones like Hsp70 assist in the proper folding of proteins, and their activity increases as a response to cellular stress such as heat, which can lead to protein misfolding. During a heat shock, cells release chaperones from the nuclear receptor/HSP complex, and simultaneously, the transcription of HSP genes is upregulated. This mechanism helps prevent damage from misfolded proteins and maintains cellular function under stress.

User Luke Pittman
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