Final answer:
Ehlers-Danlos syndrome is caused by genetic factors affecting collagen production or processing, leading to symptoms like skin and vascular issues, and joint hypermobility.
Step-by-step explanation:
The cause of Ehlers-Danlos syndrome (cutaneous asthenia, dermatosparaxis) is B) Genetic factors affecting collagen. This syndrome is a collection of heritable conditions that are primarily due to defects in the synthesis of collagen, particularly type-III collagen, which is critical for the stability and elasticity of the skin, joints, and other tissues. Mutations in the genes responsible for collagen production or processing can lead to a deficiency in the enzyme hydroxylase or to mutations in collagen amino acid sequences, resulting in a wide variety of symptoms across different types of EDS, including skin and vascular problems, joint hypermobility, and increased risk of organ and arterial rupture.