Final answer:
In atopic dermatitis, the immune response involves the production of specific antibodies, such as IgE, which bind to mast cells. Upon subsequent exposure to the allergen, the mast cells release histamine and other chemical mediators that cause inflammation and symptoms of AD.
Step-by-step explanation:
Hypersensitivity is an immune reaction that occurs when the immune system overreacts to a harmless substance. In the case of atopic dermatitis (AD), which is a type of hypersensitivity, the immune response is associated with allergies. In people, mice, dogs, and murine models, the immune response involves the production of specific antibodies, such as IgE, which bind to mast cells. Upon subsequent exposure to the allergen, the mast cells release histamine and other chemical mediators that cause inflammation and the typical symptoms of AD, such as itching and skin rash.