Question

Intermediate acting insulin

1) Trade name
2) Onset
3) Peak
4) Duration
a) Toujeo; 30-60 min; 2-4 hours; 6-8 hours
b) Novolin N; 5-15 min; 1-2 hours; 3-5 hours
c) Basaglar; 1-2 hours; 4-8 hours; 12-16 hours
d) Lente; 2-4 hours; 6-10 hours; 12-18 hours

Answer 1

Intermediate acting insulin such as Lente has an onset of 2-4 hours, peaks at 6-10 hours, and has a duration of 12-18 hours. It is not the trade name but refers to the type of insulin. Optimal diabetes management requires matching insulin therapy to patient needs, understanding insulin kinetics, and maintaining blood glucose levels.

Step-by-step explanation:

The student's query relates to the pharmacological parameters of intermediate acting insulin preparations. Among the options provided, Lente is a type of intermediate acting insulin with a trade name that was not mentioned directly. However, its pharmacokinetics include an onset of action between 2-4 hours, a peak effect occurring between 6-10 hours, and a duration of action lasting from 12-18 hours.

It is essential to match insulin therapy to each patient's needs, and understanding the onset, peak, and duration of insulin is crucial for optimizing blood glucose control in diabetes management. For example, Bovine serum insulin, which is composed of A and B peptide chains, is often used as a reference for insulin structure and function.