Final answer:
Remifentanil is the drug with the best predictable and fast offset among the listed opioids due to its rapid hydrolyzation by esterases, resulting in a quick recovery time when discontinued. The correct answer to the question is d).
Step-by-step explanation:
The drug with the best predictable and fast offset among the options provided is Remifentanil. Remifentanil is a potent, ultra-short-acting synthetic opioid analgesic drug. It is used in anesthesia because of its rapid onset and quick recovery time. Unlike other opioid derivatives such as Fentanyl, Alfentanil, and Sufentanil, Remifentanil has an ester linkage that is rapidly hydrolyzed by nonspecific tissue and plasma esterases. This unique metabolism makes Remifentanil's effects more predictable and allows for a fast offset of action after the discontinuation of the drug. Therefore, the correct answer to the question is d) Remifentanil.