Question

What is the rapid-acting, short-duration insulin?What is the onset, peak, and duration?

a. Glargine, 1-2 hours, 4-6 hours, 24 hours
b. Regular, 30 minutes-1 hour, 2-3 hours, 3-6 hours
c. Lispro, 5-15 minutes, 1-2 hours, 3-4 hours
d. NPH, 1-2 hours, 4-6 hours, 8-12 hours

Answer 1

The rapid-acting, short-duration insulin is Lispro, with an onset of
`5-15 minutes`, a peak of
`1-2 hours`, and a duration of
`3-4 hours`, it is often used to manage postprandial blood glucose levels.

Step-by-step explanation:

In the context of insulin therapy for diabetes, the rapid-acting, short-duration insulin is represented by option c: Lispro. Lispro has an onset of
`5-15 minutes`, a peak of
`1-2 hours`, and a duration of
`3-4 hours`. This type of insulin is designed to quickly decrease blood glucose levels and is often taken before meals to manage the rise in blood glucose that occurs after eating.

Lispro is synthesized as a result of modifying the insulin structure to prevent the formation of hexamers, allowing it to act faster than regular insulin. This is important for closely matching the body's natural response to a meal and managing postprandial glucose levels more effectively.