Question

Demyelinating neuropathy - Guillain-Barre refers to:

a) Accumulation of misfolded/unfolded proteins & ER stress
b) Soundex/Metaphone (avoid duplicates)
c) Disease of peripheral nerves
d) Medical condition causing tremors and involuntary movements

Answer 1

Guillain-Barré syndrome is a rare autoimmune disorder that affects the peripheral nervous system through demyelination of axons, potentially leading to severe paralysis and autonomic failures after certain infections.

Step-by-step explanation:

Guillain-Barré syndrome (Gee-YAN bah-RAY) refers to a rare autoimmune disorder that affects the peripheral nervous system. It often follows a viral or bacterial infection, leading to an autoimmune reaction where the body mistakenly attacks its own nerve cells. The hallmark of this condition is the demyelination of axons, which is the damage or destruction of the protective myelin sheath covering nerve fibers, impacting signal transmission. This results in sensory symptoms, motor deficits, and potentially life-threatening autonomic failures like heart rhythm changes or a drop in blood pressure. The condition can manifest as tingling and weakness, escalating to severe paralysis in extreme cases. Infections from various microbes, such as Campylobacter jejuni and others, have been linked to triggering Guillain-Barré syndrome.