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Which second generation is active against ANAEROBES (B.fragilis)?

2 Answers

6 votes
Cefoxitin, cefotetan and cefmetazole are more active against B.fragilis. Cefoxitin is the most effective cephalosporin against the B.fragilis group.
User DjKartright
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4 votes

Final answer:

Second-generation cephalosporins, cefoxitin and cefotetan, are effective against Bacteroides fragilis due to their beta-lactamase stability and broad spectrum of antibacterial activity.

Step-by-step explanation:

Among the second-generation cephalosporins, cefoxitin and cefotetan have the capability to act against anaerobes like Bacteroides fragilis. These antibiotics are effective due to their enhanced beta-lactamase stability and thus maintain their activity in the presence of bacterial beta-lactamase enzymes that many anaerobic bacteria produce. Cefoxitin and cefotetan exhibit a broad spectrum of activity and are particularly useful in treating infections caused by these anaerobic bacteria.

User Neville Kuyt
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