Question

What is most likely correct about the genes that are expressed as a result of the constant activation of the NF-kB pathway?

1) They cause disruption of the mitochondria
2) They contain a p65/cRel binding site in their promoter region
3) They accumulated mutations that alter function
4) They bind to STN in the cytoplasm

Answer 1

The genes expressed due to the constant activation of NF-kB most likely have a p65/cRel binding site in their promoter region, as NF-kB, when activated, can enter the nucleus to initiate transcription.

Step-by-step explanation:

The genes that are most likely correct about being expressed as a result of constant activation of the NF-kB pathway are those that contain a p65/cRel binding site in their promoter region. The NF-kB pathway, when activated, usually through the process where phosphorylation of the inhibitor IK-B dissociates the complex between it and NF-kB, allows NF-kB to enter the nucleus and stimulate gene transcription. This activation can happen due to cellular stress or DNA damage, potentially leading to increases in cellular metabolism.