Final answer:
TH1 cells, a subset of CD4+ helper T cells, produce Interleukin-2 (IL-2) and Interferon-gamma (IFN-γ), which are crucial for activating macrophages and cytotoxic T cells to clear intracellular pathogens.
Step-by-step explanation:
Type 1 T-helper Lymphocytes (TH1 cells) and Their Cytokines
Type 1 T-helper lymphocytes, or TH1 cells, are a subset of CD4+ helper T cells that play a crucial role in cellular immunity against intracellular pathogens, such as viruses and some types of bacteria. TH1 cells are characterized by their production of a specific set of cytokines including Interleukin-2 (IL-2) and Interferon-gamma (IFN-γ). These cytokines are critical for the activation of macrophages and cytotoxic T cells, which are essential for the clearance of intracellular pathogens. Interleukin-4 (IL-4) and Interleukin-10 (IL-10) are typically associated with TH2 cells, which are involved in humoral immunity and help stimulate B cells to produce antibodies.
Therefore, the correct answer is that TH1 cells produce both Interleukin-2 (IL-2) and Interferon-gamma (IFN-γ).