Final answer:
Operating systems do not generally need modification to run within virtual machines as they are designed to interact with the emulated hardware environment created by virtualization software.
Step-by-step explanation:
The statement is false. Most modern operating systems are designed to run on virtual machines without the need for modification. This is because virtualization software creates an environment that emulates computer hardware, allowing the operating system to interact with it as if it were running on a physical machine.
However, in some specialized or non-standard situations, minor tweaks or additional drivers may be required to optimize performance or enable certain features.