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Regarding tumor viruses and oncogenes, which of the following statements in correct?

A) oncogenes encode enzymes required for DNA replication such as DNA polymerase
B) tumor viruses are unique to avians (birds); they have never been observed in rodents (rats, mice) or primates (monkeys).
C) a tumor virus must become stably integrated into the host genome
D) tumor viruses can only transform epithelial cells

1 Answer

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Final answer:

The correct statement is that a tumor virus must become stably integrated into the host genome. Tumor viruses can lead to cancer by affecting proto-oncogenes or carrying oncogenes, and they are found in various species and cell types.

Step-by-step explanation:

Regarding tumor viruses and oncogenes, the statement that is correct is C) a tumor virus must become stably integrated into the host genome. Tumor viruses can lead to cancer by either carrying an overactive oncogene themselves or by inserting their genome near a proto-oncogene in the host genome, thus causing overexpression and uncontrolled cellular proliferation.

This is particularly true for retroviruses, where viral genome integration is a requisite part of their lifecycle. Contrary to some options provided, tumor viruses have been observed in a variety of species, including rodents and primates, not just avians.

Also, tumor viruses do not solely encode enzymes for DNA replication nor only transform epithelial cells; they can infect various cell types and often hijack the host machinery for replication or use their own enzymes, such as reverse transcriptase in the case of retroviruses.

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