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In human patients with familial hypercholesterolemia, which of the following occurs?

1) Increased levels of LDL cholesterol
2) Decreased levels of LDL cholesterol
3) Normal levels of LDL cholesterol
4) No effect on LDL cholesterol levels

1 Answer

2 votes

Final answer:

In human patients with familial hypercholesterolemia, increased levels of LDL cholesterol occur due to defective or absent LDL receptors, contributing to a higher risk of heart disease.

Step-by-step explanation:

In human patients with familial hypercholesterolemia (FH), an inherited form of high cholesterol, the following occurs: increased levels of LDL cholesterol. This genetic condition is characterized by defective or entirely missing LDL receptors, which leads to a reduced rate of LDL clearance from the bloodstream. As a result, individuals with FH have increased levels of LDL, which is often referred to as 'bad' cholesterol. This elevation in LDL levels contributes to a higher risk of atherosclerosis and coronary heart disease.

The management of familial hypercholesterolemia typically includes dietary modifications and increased physical activity, which can help lower total cholesterol and improve the LDL:HDL ratio. Furthermore, medical treatments such as statins may be prescribed to help reduce LDL cholesterol levels and prevent cardiovascular complications associated with FH.

In human patients with familial hypercholesterolemia, increased levels of LDL cholesterol occur. Familial hypercholesterolemia (FH) is an inherited form of high cholesterol, where individuals have a defect in the LDL receptor gene or the ApoB gene. This defect leads to a reduced rate of LDL clearance, resulting in hypercholesterolemia and an increased risk of atherosclerosis and coronary disease.

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