Final answer:
Using high temperatures with enzymatic detergents leads to enzyme denaturation, thus making them ineffective. Enzymes have a specific temperature range of activity; surpassing this range breaks down the structural bonds needed for their function.
Step-by-step explanation:
When using enzymatic detergents, higher water temperatures are not to be used because they will make the enzymes ineffective. This occurs as elevated temperatures can cause enzymes to denature, essentially changing their three-dimensional structure. Once denatured, enzymes lose their ability to function correctly as the high temperature disrupts the weak bonds that maintain their specific shape needed for their activity. Enzymes generally function best within a certain temperature range, and temperatures greater than about 37°C can lead to their denaturation and subsequent inactivity.