Question

A 28-year-old man with a history of hypercholesterolemia goes for his yearly check up to a local clinic. Upon physical examination, the patient revealed the present of Xanthomas (lipid deposition at tendons). His physician orders a series of routine blood tests. His blood lipid profile, taken under fasting conditions, revealed an unusual pattern including extremely high levels of Chylomicron Remnants. Deficiency of which of the following is the most likely cause for patient's lipidemia?

A Apo B48
B Apo E Receptor
с Аро с
D Pancreatic Lipase
e-Upoprotein Lipase

Answer 1

The patient's lipid profile indicates a likely deficiency in the Apo E Receptor, leading to the accumulation of Chylomicron Remnants and a diagnosis consistent with Hyperlipoproteinemia type III.

Step-by-step explanation:

The patient with a history of hypercholesterolemia and presence of xanthomas has been found to have extremely high levels of Chylomicron Remnants in his blood lipid profile. This suggests a deficiency in the Apo E Receptor, also known as ApoE. When ApoE receptors are deficient or defective, the clearance of chylomicron remnants is impaired, leading to their accumulation in the blood. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents, and its absence would lead to the patterns observed in Hyperlipoproteinemia type III or dysbetalipoproteinemia, which is characterized by elevation in both chylomicrons and IDL (intermediate density lipoprotein) due to cholesterol-rich VLDL (β-VLDL).