Question

The Cori cycle converts ________ to pyruvate.

a) Define and explain the Cori cycle in the context of metabolic processes.
b) Instruct the respondent to identify the substance that undergoes conversion to pyruvate in the Cori cycle.
c) Encourage a brief explanation or rationale for the chosen answer, demonstrating an understanding of the Cori cycle and its biochemical transformations.

Ensure clarity in the question to prompt an accurate identification and explanation of the substance converted to pyruvate in the Cori cycle.

Answer 1

The Cori cycle is a metabolic pathway where lactate from the muscles is converted back into glucose in the liver to be reused by the muscles, maintaining energy supply when oxygen is low. The substance converted to pyruvate in this cycle is lactate.

Step-by-step explanation:

The Cori Cycle

The Cori cycle is a metabolic process where lactate produced by anaerobic glycolysis in the muscles is converted to glucose in the liver, and then glucose is sent back to the muscles to be used or stored as glycogen. This cycle plays a crucial role in maintaining energy supply to muscle tissues during intense exercise when oxygen is scarce. The substance that is converted to pyruvate in the Cori cycle is lactate. When oxygen is not readily available, for example during strenuous exercise, muscles produce energy by anaerobic glycolysis, which leads to the formation of lactate. Lactate is then transported via the bloodstream to the liver, where it is converted back into pyruvate and then into glucose through gluconeogenesis. This glucose can then be utilized again by the muscles for energy or stored as glycogen. This conversion is important as it helps in clearing lactate from the muscles, preventing acidosis, and supplying energy during sustained muscular activity.