Final answer:
The respiratory therapist should suspect a leak in the tubing between the patient and the fluid collection chamber.
Step-by-step explanation:
The respiratory therapist should suspect that the leak in the tubing between the patient and the fluid collection chamber is causing the profuse bubbling in the water seal chamber and the low volume alarm.
The return volume of 220 mL indicates that there is not enough air going into the lung, which can be caused by a leak in the tubing connecting the patient to the fluid collection chamber.
This leak could be preventing the appropriate amount of pressure from reaching the lung and causing the chest tube drainage system to malfunction.