Question

Indicate the stereochemical configuration for the tetrahedral H₂N OH?
1) R
2) S

Answer 1

To determine the stereochemical configuration for the tetrahedral H₂N OH, assign priorities to the attached atoms and draw an arrow counterclockwise from the highest priority to the lowest priority. The resulting stereochemical configuration will be S.

Step-by-step explanation:

Solution:

1. Assign priority based on the atomic number of atoms attached to the chiral center: -Br > -NH₂
2. Swap #4 with the group away from the viewer (hashed wedge). No action needed as −H is already at the hashed wedge.
3. Draw an arrow from #1 to #2 to #3. The arrow is counterclockwise, i.e., the stereodescriptor is S.
4. Answer: S