Final answer:
Without additional context, it's not clear what the true statuses of tf2, p2, p4, p3, and p1 would be when the signal is not present. However, generally in signal transduction, proteins may be activated or inactivated in response to signals, often through phosphorylation.
Step-by-step explanation:
The question seems to be related to signal transduction or gene regulation involving proteins such as transcription factors and other cellular components that are activated or inactivated in response to certain signals. Without context, it's not possible to determine the states of tf2, p2, p4, p3, and p1 under the condition when the signal is not present. If we consider the provided reference mentioning active p53 as a transcription factor and Mdm2, which often functions to inactive p53 when it's not phosphorylated, we can infer a general principle in signal transduction: proteins can be active or inactive, usually through mechanisms such as phosphorylation which can change their activity. Based on the general principle, when a signal is not present, a protein such as tf2 (if it was a transcription factor like p53) might be in its inactive form and potentially in the nucleus, p2 and p4 might be inactive due to lack of upstream signaling, and p3 and p1 might be in their default states, active or inactive depending on their roles in the cell.