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Which of the following would you observe in a patient who lacks expression of autoimmune regulator (aire) protein?

1) Increased susceptibility to autoimmune diseases
2) Decreased susceptibility to autoimmune diseases
3) No effect on susceptibility to autoimmune diseases
4) Increased susceptibility to infectious diseases

1 Answer

5 votes

Final answer:

A patient who lacks expression of autoimmune regulator (aire) protein would observe increased susceptibility to autoimmune diseases.

Step-by-step explanation:

A patient who lacks expression of autoimmune regulator (aire) protein would observe increased susceptibility to autoimmune diseases.

The autoimmune regulator (aire) protein plays a crucial role in promoting the expression of self-antigens in the thymus, which is essential for the elimination of self-reactive T cells during development.

Without the aire protein, self-reactive T cells that should have been eliminated can escape into the circulation and target the body's own cells and tissues, leading to autoimmune diseases.

User Anton Nikiforov
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