Final answer:
A disease that affects the entire body or involves several organ systems is referred to as systemic disease. These diseases can attack and impair multiple tissues and organs.
Step-by-step explanation:
A disease that affects the entire body or involves several organ systems is referred to as Systemic disease. These diseases can attack and impair multiple tissues and organs and may involve various symptoms. Rheumatoid arthritis and systemic lupus erythematosus (SLE) are examples of systemic diseases that can affect multiple systems in the body.