Final answer:
Chemotherapy agents are bio-hazardous medications that require a spill kit for clean-up due to their dangerous properties, such as being carcinogenic or causing organ toxicity.
Step-by-step explanation:
The medication that is bio-hazardous and must be cleaned up with a spill kit is D. Chemotherapy agents. These agents are considered hazardous drugs because they contain properties that can be dangerous if exposed to people who are not receiving them therapeutically. Such properties include being carcinogenic, teratogenic, or having the potential for causing severe organ toxicity at low doses, thus requiring careful handling and disposal.
Chemotherapy agents, unlike the other medications listed such as Aspirin, Warfarin, or Insulin, need to be managed very carefully in a healthcare setting to prevent exposure to healthcare workers and the environment. Spill kits for chemotherapy agents typically include protective equipment and materials designed specifically to contain and clean up cytotoxic drugs safely.