Final answer:
The supine position is optimal for lower extremity amputation, placing the patient on their back with limbs aligned alongside the body.
Step-by-step explanation:
The best position to ensure safety and comfort for the amputation of a lower extremity is the supine position. This position involves the patient lying on their back with the upper limbs, including the palms, touching the sides and the lower limbs touching at the sides. This is described in relation to the anatomical position of the body as an upright stance, with upper limbs to the side of the body and palms facing forward, which is the standard reference point in anatomical terminology. Therefore, the correct answer to the question about the optimal position for lower extremity amputation is C) Supine position.