Final answer:
The most common organ affected by cancer in America is the lungs. Lung cancer can spread to other organs such as the brain, bones, and adrenal gland.
Step-by-step explanation:
The most common organ affected by cancer in America is the lungs.
According to the information provided, lung cancer is responsible for the most cancer-related deaths in the United States. It is also mentioned that lung cancer can metastasize, or spread, to other organs such as the brain, bones, and adrenal gland.
This is supported by the statement that metastases often occur in the brain, lungs, bones, and liver.