Final answer:
To minimize the systemic effects of eyedrops, the client should close both eyes tightly after instilling drops.
Step-by-step explanation:
The client is instructed to close both eyes tightly after instilling drops in order to minimize the systemic effects of eyedrops. This helps to prevent the drops from draining into the tear ducts and potentially entering the bloodstream. By keeping the eyes closed, the drops are more likely to stay on the surface of the eye and target the desired area.