Final answer:
The nurse should first address the client's physical safety before administering the PRN medication during an active seizure.
Step-by-step explanation:
When a patient is having an active seizure and has a PRN prescription for Lorazepam, the nurse should first address the client's physical safety by ensuring that the environment is free from any potential hazards that may harm the patient during the seizure. Once the client's physical safety is assured, the nurse can then administer the PRN medication as prescribed by the healthcare provider. After addressing the PRN medication, the nurse can focus on other needs of the client such as positioning the client to prevent any injury or harm and addressing any incontinence issues if present.