Final answer:
The manifestation that indicates the effectiveness of prednisone in a school-age child with primary nephrotic syndrome after 1 week of treatment is weight gain.
Step-by-step explanation:
The manifestation that indicates the effectiveness of prednisone in a school-age child with primary nephrotic syndrome after 1 week of treatment is weight gain.
Nephrotic syndrome is characterized by the glomerulus being damaged, causing protein in the blood to enter the urine. Prednisone helps reduce inflammation and decrease proteinuria, leading to a decrease in weight due to fluid retention.
Weight gain indicates that the medication is promoting fluid balance and reducing the loss of protein through urine.