Final answer:
The nurse should question the medication dose in the prescription for digoxin to confirm it is appropriate for the patient, ensuring both safety and therapeutic effectiveness.
Step-by-step explanation:
The nurse should question Option 3: Medication dose in the prescription reading, "digoxin 0.25 by mouth every day." Given that the prescribed medication's name, route of administration, and frequency of administration appear standard, the medication dose specified should be confirmed for accuracy. It is essential for nurses to ensure that medication dosages are appropriate to both the patient's condition and any relevant factors such as liver or kidney function, as these can affect the medication's metabolism and clearance from the body. Furthermore, the dose must be optimal to avoid toxicity and side effects while still achieving therapeutic effectiveness.