Final answer:
The biggest risk associated with insulin use is hypoglycemia.
Step-by-step explanation:
The biggest risk with insulin use is hypoglycemia, which is low blood sugar. When insulin is administered, it lowers the blood sugar level, and if too much insulin is given or the timing is not properly managed, it can lead to hypoglycemia. It is important for diabetics using insulin to monitor their blood sugar levels regularly to prevent hypoglycemia.