Final answer:
The claim that the R wave amplitude reflects tissue alignment with an ECG lead is false. Instead, R wave amplitude reflects factors like muscle mass and heart-to-chest wall distance, rather than alignment with the ECG lead.
Step-by-step explanation:
The statement that the amplitude of the R wave on an ECG reflects the alignment of the depolarizing tissue with the lead is false. The amplitude of an R wave in any ECG lead reflects various factors such as the amount of muscle mass involved in depolarization and the distance of the heart from the chest wall. However, it is not accurate to say that the amplitude reflects the alignment of the largest bulk of depolarizing tissue with the lead. As explained in the reference material, the lead II potential measures a component of the depolarization vector of the heart. The electrical activity of the heart, including the P wave, QRS complex, and T wave, can be captured on the ECG and used to analyze cardiac function.