Final answer:
The use of low dose aspirin for primary prevention of cardiovascular events is declining due to various factors such as aspirin resistance, bleeding risks, availability of alternative medications, and reduced incidence of cardiovascular diseases.
Step-by-step explanation:
The use of low dose aspirin for primary prevention of fatal and non-fatal cardiovascular events is declining due to multiple factors. The options provided in the question are all potential reasons for this decline:
- Increased prevalence of aspirin resistance: Some individuals may not respond well to aspirin therapy, reducing its effectiveness.
- Growing awareness of bleeding risks: Aspirin can increase the risk of ulcers and gastrointestinal bleeding, which has led to heightened caution.
- Availability of more effective alternative medications: There are now other medications and treatment options available for preventing cardiovascular events, which may be more effective than aspirin.
- Reduced incidence of cardiovascular diseases: With advancements in healthcare and improved preventive measures, the overall incidence of cardiovascular diseases has decreased, resulting in less need for primary prevention with aspirin.
These factors combined have contributed to the decline in the use of low dose aspirin for primary prevention of cardiovascular events.