Final answer:
Among the given options, Angiotensin-converting enzyme (ACE) inhibitors increase the risk of gastric bleeding when taken with low-dose aspirin due to their gastrointestinal side effects. This combination can lead to ulcers and an increased risk of gastrointestinal bleeding.
Step-by-step explanation:
When given with low-dose aspirin, the drug that can increase the risk of gastric bleeding among the options provided is Angiotensin-converting enzyme (ACE) inhibitors. This is because ACE inhibitors are known to cause gastrointestinal side effects, such as ulcers and bleeding, especially when taken in combination with medications like aspirin that also affect the gastrointestinal tract.
Aspirin is an anti-inflammatory and anticoagulant medication that inhibits platelet aggregation and is often used for cardiovascular disease prevention. However, it can also increase the risk of gastric bleeding and ulcers. NSAIDs, in general, are associated with gastrointestinal risks, and their long-term use should be carefully monitored to avoid gastrointestinal bleeding.
Option 1 (Proton pump inhibitors (PPIs)), Option 2 (Statins), and Option 3 (Beta-blockers) do not significantly increase the risk of gastric bleeding when taken with aspirin in comparison to Option 4 (ACE inhibitors).