Final answer:
Long-term administration of NSAIDs may lead to an increased risk of gastrointestinal bleeding, potential impairment of kidney function, and an elevated risk of cardiovascular events.
Step-by-step explanation:
Long-term administration of NSAIDs may be associated with various side effects. One potential side effect is increased risk of gastrointestinal bleeding. NSAIDs can irritate the lining of the stomach and intestines, leading to ulcers and bleeding. Another potential side effect is potential impairment of kidney function. Long-term use of NSAIDs can cause kidney damage, especially in older adults or individuals with pre-existing kidney disease. Furthermore, there is an elevated risk of cardiovascular events associated with long-term use of NSAIDs. Some studies have shown that NSAIDs may increase the risk of heart attack and stroke.