Final answer:
Thiazide diuretics can cause both hypocalcemia and hypercalcemia.
Step-by-step explanation:
Thiazide diuretics reduce the excretion of calcium by the kidneys, leading to decreased Ca2+ output.
One effect of this is hypocalcemia, which is a low level of calcium in the blood. Another effect is hypercalcemia, which is an abnormally high level of calcium in the blood.
Hypocalcemia can lead to symptoms such as muscle spasms, tingling in the fingers and face, and seizures, while hypercalcemia can cause lethargy, constipation, confusion, and loss of appetite.