Final answer:
In an educational program about bioterrorism and smallpox, the nurse should teach that the smallpox rash is expected to first appear on the face.
Step-by-step explanation:
A nurse is developing an educational program about bioterrorism and smallpox. It is important to know where a rash associated with a disease like smallpox is expected to first appear. Unlike chickenpox, which typically shows a rash starting on the face, spreading to the trunk, and then to the extremities, smallpox differs in its progression. The nurse should include in the teaching that the smallpox rash is expected to first appear on the face. This is a distinctive feature of the disease, and such knowledge is crucial when distinguishing it from other infections like chickenpox and further educating individuals on bioterrorism preparedness.