Final answer:
Progestins can increase the risk of cardiovascular complications and have negative side effects such as an increased risk of stroke or heart attack, blood clots, and various types of cancer.
Step-by-step explanation:
The use of progestins in female clients can increase the risk of cardiovascular complications. Negative side effects of progestins include an increased risk of stroke or heart attack, blood clots, breast cancer, ovarian cancer, endometrial cancer, gall bladder disease, and possibly dementia.