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Ovulation induction in patients with Primary Ovarian Failure:

a. Clomiphene citrate
b. In vitro fertilization (IVF)
c. Human menopausal gonadotropin (hMG)
d. Gonadotropin-releasing hormone (GnRH) agonists

1 Answer

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Final answer:

In the case of Primary Ovarian Failure (POF), in vitro fertilization (IVF) is often the recommended treatment. IVF involves a course of gonadotropins including FSH analogs and LH analogs to stimulate the development of multiple follicles and induce ovulation, followed by egg retrieval and, if required, administration of hCG.

Step-by-step explanation:

Ovulation induction is a process used in treating infertility, specifically when the issue lies with the female's ovulation. In cases of Primary Ovarian Failure (POF), the ovaries do not produce eggs normally, and therefore in vitro fertilization (IVF) is often the recommended treatment. IVF is an involved procedure that typically starts with egg collection followed by gonadotropin hormone treatments which include follicle-stimulating hormone (FSH) analogs to increase the number of oocytes and ends with a luteinizing hormone (LH) analog to trigger ovulation. The eggs are then retrieved through ultrasound-guided oocyte retrieval. If ovulation is successfully induced, human chorionic gonadotropin (hCG) may be used to mimic the action of the hormone that naturally induces ovulation and support the early pregnancy.

Options such as clomiphene citrate, human menopausal gonadotropin (hMG), and gonadotropin-releasing hormone (GnRH) agonists are typically used in cases where there's some ovarian function to stimulate or regulate. These methods are less likely to be successful in cases of POF where ovarian function is severely compromised or non-existent, making IVF the more likely option.

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