Question

BiP and other ER chaperones function to:

a. Recognize unfolded or misfolded proteins and help them attain their native structure.
b. Facilitate protein degradation in the endoplasmic reticulum.
c. Regulate gene expression in the endoplasmic reticulum.
d. Assist in protein transport to the Golgi apparatus.

Answer 1

ER chaperones like BiP recognize and assist in the correct folding of proteins, preventing aggregation and ensuring functionality.

Step-by-step explanation:

BiP and other ER chaperones function to recognize unfolded or misfolded proteins and help them attain their native structure. This involves proper "folding" of the polypeptide and, often, the association of multiple polypeptide subunits into a distinct three-dimensional structure. ER chaperones act by preventing the aggregation of polypeptides that make up the complete protein structure, ensuring that even under abnormal conditions such as unusual temperature or pH, the proteins can fold correctly. Once the target protein is properly folded, chaperones disassociate from it. This is critical for the protein to perform its intended function within the cell. Therefore, the correct answer to the given question is (a) Recognize unfolded or misfolded proteins and help them attain their native structure.