Question

P53 tumor suppressor G1 checkpoint (Step 2):

a) Cyclin-dependent kinase activation
b) DNA replication
c) Check for cell size
d) Check for proper chromosome alignment

Answer 1

The p53 tumor suppressor G1 checkpoint at step 2 involves cyclin-dependent kinase activation, checking for cell size, and checking for proper chromosome alignment. This checkpoint halts the cell cycle if there is damaged DNA, and prevents the duplication of damaged chromosomes.

Step-by-step explanation:

The p53 tumor suppressor G1 checkpoint at step 2 involves the following processes:

1. Cyclin-dependent kinase activation
2. Check for cell size
3. Check for proper chromosome alignment

This checkpoint is important for ensuring that the cell cycle is halted if there is damaged DNA, and preventing the duplication of damaged chromosomes. If damaged DNA is detected, p53 halts the cell cycle and recruits enzymes to repair the DNA. If the DNA cannot be repaired, p53 can trigger apoptosis, or cell death.