Final answer:
Liver function tests (LFTs) are required before obtaining a refill of isotretinoin for severe nodulocystic acne vulgarism because the medication can potentially cause liver abnormalities.
Step-by-step explanation:
The nurse should advise the client that liver function tests (LFTs) are required before obtaining a refill of isotretinoin for severe nodulocystic acne vulgarism. LFTs are blood tests that can show if the liver is functioning normally. Elevated levels of certain enzymes and proteins in the blood can indicate liver disease or dysfunction. It is important to monitor liver function because isotretinoin can potentially cause liver abnormalities.