Final answer:
Yes, it is true that the interstitial cells of Cajal are responsible for initiating peristalsis in the GI tract. They generate the rhythmic contractions needed to move food through the digestive system.
Step-by-step explanation:
The statement that the interstitial cells of Cajal spontaneously depolarize to initiate peristalsis of the GI tract is true. These cells act as pacemakers within the gastrointestinal (GI) smooth muscle layers and are responsible for creating the rhythmic contractions known as peristalsis. This movement is crucial for transporting food along the digestive tract. It's important to note that while other cells, like columnar epithelial cells, play a role in the digestive system, they are not directly involved in the propulsion of food by peristalsis. In the listed options, columnar epithelial cells' contribution to peristalsis is incorrectly stated; they facilitate absorption rather than movement.