Question

After the AP2 cargo binding site is exposed, what does this allow?

A) Formation of clathrin-coated pits
B) Interaction with GTPases
C) Binding to transmembrane receptors
D) Sorting of cargo into vesicles

Answer 1

Exposure of the AP2 cargo binding site facilitates the formation of clathrin-coated pits, which is a critical step in receptor-mediated endocytosis for internalizing specific extracellular substances into the cell.

Step-by-step explanation:

Once the AP2 cargo binding site is exposed, it allows for the formation of clathrin-coated pits. This process is part of receptor-mediated endocytosis, where receptors bind to specific extracellular substances, and upon binding their ligands, cluster and invaginate to form a clathrin-coated vesicle. This is essential for the internalization of selected cargo into the cell. The clathrin-coated vesicles then undergo a series of processes where they shed their clathrin coat and eventually fuse with early endosomes for sorting and distribution within the cell.