Final answer:
A water-soluble oral drug will readily diffuse into the GI tract without the need for active transport or fatty foods for absorption.
Step-by-step explanation:
An oral drug that is water soluble will readily diffuse into the GI tract. Water-soluble nutrients are typically absorbed by simple diffusion. Most water-soluble vitamins, like most B vitamins and vitamin C, enter the absorptive cells (enterocytes) directly, without the need for active transport or the presence of dietary fats. Unlike fat-soluble vitamins, they do not need to be taken with fatty foods to enhance their absorption. Therefore, an oral water-soluble drug generally does not require special conditions like fatty foods or an empty stomach for its absorption.