Final answer:
Most topical antiviral medications require multiple applications per day, not just once, and the frequency varies by medication and condition. Oral administration is more convenient for treating systemic infections at home.
Step-by-step explanation:
It is false that most topical antiviral medications are applied only once a day. The frequency of application depends on the specific medication and the condition being treated. For example, some creams for herpes simplex virus, such as n-docosanol, may be applied several times per day to reduce symptoms like itching and tingling. For systemic infections, an oral administration would be more convenient for home treatment compared to other methods like intravenous or parenteral.