Final answer:
Hemolytic disease of the newborn (HDN) occurs when maternal anti-Rh antibodies target fetal Rh+ red blood cells. Rho(D) immune globulin can prevent the formation of anti-D antibodies in Rh- mothers.
Step-by-step explanation:
Hemolytic disease of the newborn (HDN) is a type II hypersensitivity reaction that occurs when maternal anti-Rh antibodies cross the placenta and target fetal Rh+ red blood cells for lysis. This condition, also called erythroblastosis fetalis, can cause anemia in mild cases and be severe enough to be fatal for the fetus or newborn. HDN can be prevented by administering Rho(D) immune globulin to Rh- mothers, which prevents the formation of anti-D antibodies.