Final answer:
The nurse should withhold the spironolactone and notify the healthcare provider when transcribing a prescription for a client receiving an ACE inhibitor to avoid the risk of hyperkalemia.
Step-by-step explanation:
The nurse should withhold the spironolactone (Aldactone) and notify the healthcare provider when transcribing a new prescription for a client who receives an angiotensin-converting enzyme (ACE) inhibitor. ACE inhibitors and spironolactone have the potential to cause hyperkalemia (high potassium levels), and taking them together can increase the risk of this adverse effect.