Final answer:
A person can be predisposed to a perforated peptic ulcer due to factors such as Helicobacter pylori infection, chronic use of NSAIDs, tobacco smoking, and stress.
Step-by-step explanation:
Several factors can predispose a person to a perforated peptic ulcer. One major factor is the infection with the bacterium Helicobacter pylori, which is the most common cause of peptic ulcers. Other factors include the chronic use of non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin or ibuprofen, tobacco smoking, and stress. These factors can weaken the protective mucosal barrier of the stomach lining and make it more susceptible to ulceration.