Final answer:
Long-term use of typical antipsychotics can lead to Tardive dyskinesia, a condition characterized by involuntary, repetitive movements, resulting from the drugs' effects on dopamine neurotransmission in the basal nuclei.
Step-by-step explanation:
Long-term use of a typical antipsychotic can produce a serious motor condition marked by involuntary, repetitive movements known as Tardive dyskinesia (C). This condition often arises as a result of prolonged treatment with antipsychotics, which are used to manage symptoms of mental disorders such as schizophrenia. These drugs, while effective for treating psychotic symptoms, block dopamine receptors and decrease dopamine neurotransmission in the brain. This impact on the dopaminergic system in the basal nuclei can lead to movement disorders resembling those seen in Parkinson's disease and may manifest as Tardive dyskinesia after long-term use.