Final answer:
For mild symptoms of Systemic Lupus Erythematosus (SLE), the first-line treatment is hydroxychloroquine combined with NSAIDs. Hydroxychloroquine works on the immune system to reduce autoimmunity, which is effective for managing SLE, even though it may not provide immediate effects.
Step-by-step explanation:
The first-line treatment of Systemic Lupus Erythematosus (SLE) with mild symptoms is hydroxychloroquine plus nonsteroidal anti-inflammatory drugs (NSAIDs). Hydroxychloroquine is an anti-inflammatory drug used to treat inflammation in patients with various autoimmune diseases, including SLE. Although its mechanism of action is not entirely clear, it is believed to interfere with antigen processing and activation of autoimmunity. While hydroxychloroquine may not provide immediate effects as other anti-inflammatory drugs, it's considered effective for SLE management, especially when used alongside NSAIDs to provide symptom relief.
In comparison, systemic corticosteroids are typically reserved for more acute flare-ups or severe presentations due to their more potent immunosuppressive effects and a higher profile of side effects. Anakinra and methotrexate may be used in certain SLE cases but are not often first-line treatments for mild symptoms.