Final answer:
Supraclavicular lymph node enlargement may be the first sign of metastatic cancer.
Step-by-step explanation:
Supraclavicular lymph nodes, located along the transverse cervical artery, are clinically significant because their enlargement may be the first sign of metastatic cancer. When cancer cells spread from their site of origin, they often travel through the lymphatic system and can accumulate in the nearby lymph nodes. Enlargement of supraclavicular lymph nodes can indicate the presence of cancer cells that have metastasized from a primary tumor elsewhere in the body.